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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2215374Generated: October 25, 2026

1-Isoquinolinamine → 4-(5-Fluoro-2-methoxyphenyl)-1-(isoquinolin-1-ylamino)-4-methyl-2-(trifluoromethyl)pentan-2-ol

https://huagongshe.com/reaction/2215374

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-IsoquinolinamineHCID 73742—
Reactant2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxiraneHCID 16099239—
SolventEthyl acetate hexaneHCID 21226206—
Product4-(5-Fluoro-2-methoxyphenyl)-1-(isoquinolin-1-ylamino)-4-methyl-2-(trifluoromethyl)pentan-2-olHCID 2194881221.9%

Reaction Steps

Analogously to Example 1, 200 mg (0.68 mmol) of 2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)oxirane and 99 mg (0.68 mmol) of 1-aminoisoquinoline are reacted. After chromatography on silica gel with hexane-ethyl acetate (0–60%), 65 mg of product is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07109212B2
Source datasetuspto-grants-2006_09
ORD IDord-ca43476bdbfd438bac61b8a94f347098
Source noteuspto-grants-2006_09