HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylamino-5-nitroquinoline → 2-Acetylamino-5-aminoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylamino-5-nitroquinoline | HCID 21948873 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | 2-Acetylamino-5-aminoquinoline | HCID 21948829 | — |
Reaction Steps
400 mg (1.7 mmol) of 2-acetylamino-5-nitroquinoline and 105 mg of 10% Pd—C are stirred in 20 ml of ethyl acetate-MeOH (3:1) for 4 hours in a hydrogen atmosphere at room temperature. The batch is filtered, concentrated by evaporation and purified by column chromatography on silica gel with hexane-ethyl acetate: 210 mg of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07109212B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-4d1df30f3c5244ae9976f182bf3c359f |
| Source note | uspto-grants-2006_09 |