Pyridine → HCID 21948814, compound

Participants

Reaction Conditions

Reaction Steps

580 mg (2.4 mmol) of 2-methylamino-5-nitroquinoline is stirred with 4 ml (50 mmol) of pyridine and 2 ml (21 mmol) of acetic anhydride for 15 hours at room temperature and stirred for 4.5 hours at 60° C. The batch is diluted with ethyl acetate, poured into saturated NaHCO3 solution, stirred for 30 minutes, and extracted with ethyl acetate. The extracts are dried (Na2SO4) and concentrated by evaporation. The residue is purified on silica gel with hexane-ethyl acetate: 660 mg of a yellow solid.

Provenance & Evidence