反应详情

A solution that consists of 290 mg (1.55 mmol) of 5-aminoquinoline-2-carboxylic acid amide, 616 mg (2.0 mmol) of 4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanal and 3.80 ml of concentrated acetic acid in 30 ml of toluene is refluxed for 20 hours in a water separator. Then, the solvent is removed in a vacuum. After the residue is purified on silica gel with hexane/ethyl acetate (0–70%), 438 mg (59% of theory) of the product is obtained.

1. customThen, the solvent is removed in a vacuum
2. customAfter the residue is purified on silica gel with hexane/ethyl acetate (0–70%), 438 mg (59% of theory) of the product
3. customis obtained