Boron tribromide → 1-(Quinolin-5-ylamino)-3-[1-(5-fluoro-2-hydroxyphenyl)cycloprop-1-yl]-2-(trifluoromethyl)propan-2-ol

Participants

Reaction Steps

Analogously to Example 38, 330 mg (0.76 mmol) of 1-(quinolin-5-ylamino)-3-[1-(5-fluoro-2-methoxyphenyl)cycloprop-1-yl]-2-(trifluoromethyl)propan-2-ol is reacted with 3.80 ml (3.80 mmol) of a 1 M boron tribromide solution in 6.90 ml of dichloromethane. After 2 hours, the reaction is halted. The recrystallization from ethyl acetate and methanol yields 292 mg (91% of theory) of the product.

Provenance & Evidence