Toluene → HCID 21948929, compound

HRID 2215436Notes

Reaction equation

HRID 2215436 reaction equation
[OH:1][CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:13]([O-:15])=[O:14])[N:4]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17].C1(C)C=CC=CC=1.CCCCCC.C(OCC)(=O)C>N1C=CC=CC=1>[C:16]([O:1][CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:13]([O-:15])=[O:14])[N:4]=1)(=[O:18])[CH3:17]

Participants

6

Reactant 4

HCID 1140TolueneHCID 7918Acetic AnhydrideHCID 49133605-Nitro-2-quinolinemethanolHCID 21226206Ethyl acetate hexane

Product 1

HCID 21948929HCID 21948929, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution that consists of 390 mg (1.91 mmol) of 2-(hydroxymethyl)-5-nitroquinoline and 2.5 ml of acetic acid anhydride in 5.0 ml of pyridine is allowed to stir for 24 hours at room temperature. After repeated co-evaporation with toluene and subsequent chromatography on silica gel with hexane-ethyl acetate (0–100%), 410 mg (87% of theory) of the product is obtained.

Workup

  1. customis obtained

Sources & evidence

ORD record
ord-25b6d6aa507f4bd4a59892a1fc16c4ae
Source dataset
uspto-grants-2006_09
Patent number
US07109212B2

Reaction notes

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