HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Chloro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal → HCID 69202580, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Chloro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal | HCID 21948891 | — |
| Reactant | Methyl 5-aminoquinoline-2-carboxylate | HCID 45089604 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 69202580 | HCID 69202580 | — |
Reaction Steps
Analogously to Example 37, 160 mg (0.47 mmol) of 4-(5-chloro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal is reacted with 116 mg (0.57 mmol) of 5-aminoquinoline-2-carboxylic acid methyl ester in 1.0 ml of concentrated acetic acid and 20 ml of toluene. After working-up and purification on silica gel with hexane-ethyl acetate (0–100%), 110 mg (45% of theory) of the product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07109212B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-9999cf9c0a82497e8b21a23659a92c4e |
| Source note | uspto-grants-2006_09 |