Water → HCID 21948896, compound

Participants

Reaction Steps

175 mg (0.62 mmol) of 4-(2,5-difluorophenyl)-4-methyl-2-(trifluoromethyl)-pentanal and 125 mg (0.78 mmol) of 5-amino-2-methylquinoline are stirred in 10 ml of toluene and 3 ml of acetic acid for 18 hours at room temperature and refluxed for another 2 hours in a water separator. The crude product is reduced analogously to 79 with 120 mg (3.16 mmol) of NaBH4 in 5 ml of acetic acid. After chromatography on silica gel with hexane-ethyl acetate (30%), 45 mg of product is obtained.

Provenance & Evidence