Benzyl 4-(2-hydroxy-2-methylpropionyl)piperazine-1-carbamate → 2-Hydroxy-2-methyl-1-(piperazin-1-yl)propan-1-one

HRID 2215513노트

반응식

HRID 2215513 반응식
[OH:1][C:2]([CH3:23])([CH3:22])[C:3]([N:5]1[CH2:10][CH2:9][N:8](NC(OCC2C=CC=CC=2)=O)[CH2:7][CH2:6]1)=[O:4]>CO.[Pd]>[OH:1][C:2]([CH3:23])([CH3:22])[C:3]([N:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)=[O:4]

참가 물질

4

반응물 1

HCID 69316719Benzyl 4-(2-hydroxy-2-methylpropionyl)piperazine-1-carbamate

생성물 1

HCID 219492932-Hydroxy-2-methyl-1-(piperazin-1-yl)propan-1-one수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Benzyl 4-(2-hydroxy-2-methylpropionyl)piperazine-1-carbamate (2.82 g, 9.20 mmol) synthesized in Production example 28-1 was dissolved in methanol (100 ml) under nitrogen atmosphere; 10% palladium on carbon (50% wet, 1.96 g) was added thereto, the reaction system was purged with hydrogen at atmospheric pressure; and the reaction mixture was stirred overnight. After the reaction system was purged with nitrogen, the catalyst was filtered out, and washed with methanol, then the solvent, together with the filtrate and the washing solution, was distilled off. The residue was dried under reduced pressure to yield the title compound (1.58 g, 9.20 mmol, quantitative) as a colorless oil.

후처리

  1. customthe reaction system was purged with hydrogen at atmospheric pressure
  2. customAfter the reaction system was purged with nitrogen
  3. filtrationthe catalyst was filtered out
  4. washwashed with methanol
  5. distillationthe solvent, together with the filtrate and the washing solution, was distilled off
  6. customThe residue was dried under reduced pressure

출처 및 근거

ORD 기록
ord-88cfb7834c1242f5ac0f74955f8ebf57
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07109219B2

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