HCID 69329080, compound → 2-(Dimethylamino)-1-(piperazin-1-yl)ethan-1-one

Benzyl 4-(2-dimethyaminoacetyl)piperazine-1-carbamate (954 mg, 3.12 mmol) synthesized in Production example 51-1 was dissolved in methanol (50 ml) under nitrogen atmosphere; 10% palladium on carbon (50% wet, 665 mg) was added thereto; the reaction system was purged with hydrogen at atmospheric pressure; and the reaction mixture was stirred overnight. After the reaction system was purged with nitrogen, the catalyst was filtered out, and washed with methanol. The solvent, together with the filtrate and washing solution, was distilled off, and the residue was dried under reduced pressure to yield the title compound (508 mg, 2.97 mmol, 95.0%) as a colorless oil.

1. customthe reaction system was purged with hydrogen at atmospheric pressure
2. customAfter the reaction system was purged with nitrogen
3. filtrationthe catalyst was filtered out
4. washwashed with methanol
5. washThe solvent, together with the filtrate and washing solution
6. distillationwas distilled off
7. customthe residue was dried under reduced pressure

ORD record

ord-64a6a9c5e50b4ecb9f52a8b1975241a2

Source dataset

uspto-grants-2006_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07109219B2