HCID 21951480, compound → HCID 21951488, compound

Participants

Reaction Steps

Into a 250 mL Parr hydrogenation flask was charged [2,5-bis(2-trifluoromethyl-4-nitrophenoxy)phenyl]diphenylphosphine oxide (2.55 g, 0.0037 mol), ethanol (25 mL), and 10% Pd/C (0.27 g). The mixture was degassed prior to the introduction of hydrogen gas. The mixture was agitated under a hydrogen atmosphere for ˜24 hours at room temperature. After degassing the solution, the Pd/C was removed by filtration and the solution added to stirred water to afford an off white solid. The crude solid was collected via filtration, washed with water, and dried at room temperature to afford 1.23 g (53% crude yield). The solid exhibited no melting peaks as determined by DSC at a heating rate of 10° C./min.

Provenance & Evidence