HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-Benzyl-3-methyl-5-nitroindazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzylhydrazine dihydrochloride | HCID 146540 | — |
| Reactant | 1-(2-Fluoro-5-nitrophenyl)ethan-1-one | HCID 2781067 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Benzyl-3-methyl-5-nitroindazole | HCID 21952162 | — |
Reaction Steps
2-Fluoro-5-nitroacetophenone (H. Sato et al, Bioorganic and Medicinal Chemistry Letters, 5(3), 233–236,1995) (0.24 g) was treated with triethylamine (0.73 ml) and benzyl hydrazine dihydrochloride (0.255 g) in ethanol (20 ml) at reflux under N2 for 8 days. The mixture was cooled and the solid 1-benzyl-3-methyl-5-nitroindazole (0.16 g) was collected by filtration; m/z (M+1)+ 268.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07109333B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-32e790fce3114e2eaff68c921f3faf16 |
| Source note | uspto-grants-2006_09 |