HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Phenylmethyl)-1H-indazol-5-amine → (1-Benzylindazol-5-yl)-(6-iodoquinazolin-4-yl)-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Phenylmethyl)-1H-indazol-5-amine | HCID 212069 | — |
| Reactant | 4-Chloro-6-iodoquinazoline | HCID 11173809 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (1-Benzylindazol-5-yl)-(6-iodoquinazolin-4-yl)-amine hydrochloride | HCID 21952130 | 92% |
Reaction Steps
Prepared according to Procedure A from 4-chloro-6-iodoquinazoline (5.8 g) was treated with 5-amino-1-benzyl-1H-indazole (3.90 g) in acetonitrile (500 ml) at reflux under N2 for 18 hours. Subsequent cooling and filtration gave the title compound (8.26 g); m/z (M+1)+ 478.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07109333B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-4130f2f142254ab1baaee4803aced6bc |
| Source note | uspto-grants-2006_09 |