2-(Methylsulfonyl)ethanamine → N-[4-(benzyloxy)phenyl]-6-[4-({[2-(methanesulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine

Participants

Role	Name	HCID	Charge
Reactant	2-(Methylsulfonyl)ethanamine	HCID 4340561	—
Reactant	5-(4-{4-Benzyloxyanilino}-6-quinazolinyl)-furan-3-carbaldehyde	HCID 21952275	—
Product	N-[4-(benzyloxy)phenyl]-6-[4-({[2-(methanesulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine	HCID 9828335	—

Reaction Steps

Prepared according to Procedure D from 5-(4-{4-benzyloxyanilino}-6-quinazolinyl)-furan-3-carbaldehyde (0.6 equiv) and 2-methanesulphonyl-ethylamine (1 equiv). 1HNMR 400 MHz, d6DMSO 9.51 (bs,2H), 9.11 (s, 1H), 8.79 (s, 1H), 8.29 (d, 1H), 8.06 (s, 1H), 7.90 (d, 1H), 7.60 (d, 2H), 7.5–7.3 (m, 5H), 7.11 (d, 2H), 5.14 (s, 2H), 4.14 (bs, 2H), 3.6–3.5 (m, 3H), 3.12 (s, 3H); MS m/z 529 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07109333B2
Source dataset	uspto-grants-2006_09
ORD ID	ord-fc204589d30d402a9e8bc62165f9ae35
Source note	uspto-grants-2006_09