2,6-Difluoroaniline → HCID 21056592, compound

HRID 2215902Notes

Reaction equation

HRID 2215902 reaction equation
C(OC([N:8]1[CH2:25][CH2:24][C@@H:11]2[N:12]([CH3:23])[C:13]3[C:14]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:16]=[CH:17][C:18]=3[C@H:10]2[CH:9]1Br)=O)(C)(C)C.[F:27][C:28]1[CH:34]=[CH:33][CH:32]=[C:31]([F:35])[C:29]=1[NH2:30]>>[F:27][C:28]1[CH:34]=[CH:33][CH:32]=[C:31]([F:35])[C:29]=1[NH:30][C:16]1[CH:15]=[C:14]([C:19]([F:22])([F:21])[F:20])[C:13]2[N:12]([CH3:23])[C@H:11]3[CH2:24][CH2:25][NH:8][CH2:9][C@H:10]3[C:18]=2[CH:17]=1

Participants

3

Reactant 2

HCID 796472,6-DifluoroanilineHCID 67182044HCID 67182044, compound

Product 1

HCID 21056592HCID 21056592, compound

Procedure

The title compound was prepared by following the general coupling procedure as a yellow solid (12 mg, 31%) from (4aS,9bR)-bromo-5-methyl-6-trifluoromethyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester (Example 45, 41 mg, 0.095 mmol) and 2,6-difluoroaniline (39 mg, 0.30 mmol). MS (APCI): 384 (base, M+H).

Sources & evidence

ORD record
ord-5340a77467a44da78cc359589af312c6
Source dataset
uspto-grants-2006_09
Patent number
US07109339B2

Reaction notes

Loading…