Trifluoroacetic acid → HCID 21952748, compound

Participants

Reaction Steps

A solution of 6-cyano-1,3,4,5-tetrahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester (1.00 g) in CH2Cl2 (10 mL) was treated with TFA (2 mL). The reaction mixture was stirred for 7 h then converted to the free base with K2CO3 to provide 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-6-carbonitrile (0.66 g, 99%) as a white solid: mp 230–235° C.; 1H NMR (300 MHz, CD3OD) δ 7.71–7.69 (m, 1H), 7.50–7.46 (m, 1H), 7.16–7.11 (m, 1H), 4.05–4.04 (m, 2H), 3.26–3.21 (m, 2H), 2.91–2.87 (m, 2H); ESI MS m/z 198 [C12H, N3+H]+.

Provenance & Evidence