Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Amino-2-(trifluoromethyl)pyridine → HCID 58700383, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Amino-2-(trifluoromethyl)pyridine | HCID 2737744 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 반응물 | (4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester | HCID 58700289 | — |
| 반응물 | 5-Methyl-8-(pyridinylamino)-6-trifluoromethyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester | HCID 67183531 | — |
| 생성물 | HCID 58700383 | HCID 58700383 | — |
반응 단계
The title compound was prepared by following the general method for (5-methyl-6-trifluoromethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indol-8-yl)-pyridin-3-yl-amine (Method A) as an oil (25 mg, 13%) from (4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester (Example 158, 196 mg, 0.5 mmol), 6-trifluoromethyl-pyridin-3-ylamine (141 mg, 1.5 mmol) and NaOt-Bu (144 mg, 1.5 mmol). MS (ESI): 374 (base, M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07109339B2 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-3d4f48aca97244ceab7a02916be7efcc |
| 출처 메모 | uspto-grants-2006_09 |