Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Amino-2,5-dichloropyridine → HCID 58700330, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Amino-2,5-dichloropyridine | HCID 2799999 | — |
| 반응물 | Sodium t-butoxide | HCID 23676156 | — |
| 반응물 | (4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester | HCID 58700289 | — |
| 반응물 | HCID 67183531 | HCID 67183531 | — |
| 생성물 | HCID 58700330 | HCID 58700330 | — |
반응 단계
The title compound was prepared by following the general method for (5-methyl-6-trifluoromethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indol-8-yl)-pyridin-3-yl-amine (Method A) as a yellow solid (60 mg, 32%) from (4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester (Example 158, 196 mg, 0.5 mmol), 2,5-dichloro-pyridin-3-ylamine (186 mg, 1.5 mmol) and NaOt-Bu (144 mg, 1.5 mmol). MS (ESI): 375 (base, M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07109339B2 |
| 출처 데이터셋 | uspto-grants-2006_09 |
| ORD ID | ord-c61c6230a16442fea9d32fb941a63c6e |
| 출처 메모 | uspto-grants-2006_09 |