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3-Amino-2-chloro-6-(trifluoromethyl)pyridine → HCID 58700406、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Amino-2-chloro-6-(trifluoromethyl)pyridine | HCID 2737646 | — |
| 反応物 | Sodium t-butoxide | HCID 23676156 | — |
| 反応物 | (4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester | HCID 58700289 | — |
| 反応物 | 5-Methyl-8-(pyridinylamino)-6-trifluoromethyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester | HCID 67183531 | — |
| 生成物 | HCID 58700406 | HCID 58700406 | — |
反応手順
The title compound was prepared by following the general method for (5-methyl-6-trifluoromethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indol-8-yl)-pyridin-3-yl-amine (Method A) as an oil (40 mg, 20%) from (4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester (Example 158, 196 mg, 0.5 mmol), 2-chloro-6-trifluoromethyl-pyridin-3-ylamine(186 mg, 1.5 mmol) and NaOt-Bu (144 mg, 1.5 mmol). MS (ESI): 408 (base, M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07109339B2 |
| 出典データセット | uspto-grants-2006_09 |
| ORD ID | ord-16f95616560245849c47bb52dc3ad96f |
| 出典メモ | uspto-grants-2006_09 |