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HRID 2215930作成日：2026年10月25日

(4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester → (4aS,9bR)-8-iso-butyl-5-methyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole-6-carbonitrile

https://huagongshe.com/reaction/2215930

反応式

関与物質

役割名称HCID仕込み量
反応物(4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl esterHCID 58700289—
反応物HCID 178448254HCID 178448254—
触媒HCID 178418397HCID 178418397—
生成物(4aS,9bR)-8-iso-butyl-5-methyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole-6-carbonitrileHCID 58700369—

反応手順

Following the general procedure for Example 127–146, the title compound was prepared (13 mg, 48%) as a light yellow oil using (4aS,9bR)-8-bromo-6-cyano-5-methyl-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester (Example 158, 40 mg, 0.10 mmol), iso-butylzinc bromide (0.5 M in THF, 2.5 mole equivalent) and Pd(PPh3)4 (0.06 mole equivalent).: MS (ESI): 270 (base, M+H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07109339B2
出典データセットuspto-grants-2006_09
ORD IDord-f8421337e9e0442e805f6928e570f7a4
出典メモuspto-grants-2006_09