反应详情

In a mixture of 6 ml of ethanol and 4 ml of glacial acetic acid, 1 g (3.3 mmol) of 3-hydroxy-11β-methoxy-estra-1,3,5(10)-trien-17-one and 0.7 g (3.8 mmol) of toluene-4-sulfonic acid hydrazide are refluxed. After a reaction time of about 5 hours at boiling heat, the reaction mixture is cooled, and the product is isolated in about 100 ml of water by addition in drops. By boiling the crude product in n-hexane, the water that is contained is azeotropically removed.

1. temperatureare refluxed
2. temperatureAfter a reaction time of about 5 hours at boiling heat
3. temperaturethe reaction mixture is cooled
4. customthe water that is contained is azeotropically removed