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HRID2215944

反应详情

EQUATION

反应方程式

HRID 2215944 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：c1ccncc1
HCID1049

Pyridine

C5H5N

结构：CC[Si](Br)(CC)CC
HCID70680

Silane, bromotriethyl-

C6H15BrSi

结构：CO[C@H]1C[C@]2(C)C=CC[C@H]2[C@@H]2CCc3cc(O)ccc3[C@H]21
HCID69529888

未命名化合物

PRODUCTS

生成物

1
结构：CC[Si](CC)(CC)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2[C@@H](OC)C[C@]2(C)C=CC[C@@H]12
HCID69529296

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：COC(C)(C)C
溶剂HCID15413

Methyl tert-butyl ether

C5H12O

PROCEDURE

实验过程

284 mg (1 mmol) of 11β-methoxy-estra-1,3,5(10),16-tetraen-3-ol is reacted in 10 ml of tert-butylmethyl ether and 1 ml of pyridine with 0.6 ml of triethylbromosilane. After 1 hour, 30 ml of water is added to the reaction suspension. The organic phase is separated, washed, dried and concentrated by evaporation in a vacuum. The oily product that is thus obtained is used immediately in the next stage (hydroboration). Yield: 380 mg (95% of theory)

WORKUP

后处理

  1. customThe organic phase is separated
  2. washwashed
  3. customdried
  4. concentrationconcentrated by evaporation in a vacuum
  5. customThe oily product that is thus obtained