Acetyl bromide → HCID 21886672, compound

Participants

Reaction Conditions

Reaction Steps

Acetyl bromide (5 mL) was cooled to 0° C. To this was added 4-Nitro-3-methyl-pyridin-1-ol (1000 mg, 6.48 mmol) portionwise while maintaining temperature. After the addition was complete, the reaction was heated to 50° C. and stirred for 2 hours. The reaction was then cooled to 0° C., quenched with ice and neutralized with solid Na2CO3 (pH=8). The neutral aqueous reaction mixture was extracted into DCM. The organic layer was dried (MgSO4), the solvents were removed in vacuo resulting in the title compound as a yellow solid (1.05 mg, 86%). ESI-MS (m/z): Calcd. for C6H6BrNO: 188.0 (M+1); found: 188.0.

Provenance & Evidence