反应详情

4-Amino-3-bromo-5-nitrobenzenesulfonamide ((U.S. Pat. No. 3,987,199) 1 g, 3.17 mmol) was heated at 95° C. for 3 h in chlorosulfonic acid (10 mL). The solution was cooled then poured onto ice and then filtered. The solid was redissolved in DCM and dried over sodium sulfate. Removal of the solvent yielded the product (960 mg) which was used without further purification.

1. temperatureThe solution was cooled
2. additionthen poured onto ice
3. filtrationfiltered
4. dissolutionThe solid was redissolved in DCM
5. dry with materialdried over sodium sulfate
6. customRemoval of the solvent