Methylamine → HCID 86592812, compound

Participants

Reaction Steps

The reaction was performed with 2′,3′,5′-tri-O-acetyl-2-iodo-8-bromoadenosine (6, 100 mg, 0.17 mmol) and methylamine (16 ml, 40% w/v in water). Yield 54.6 mg (0.13 mmol, 77%), mp 162–164÷C; 1H NMR (DMSO-d6) δ 7.02 (d, 1H, J=5.15 Hz, NH), 6.93 (s, 2H, NH2), 5.77 (d, 1H, J=7.56 Hz, H-1′), 5.66 (t, 1H, J=4.81 Hz, OH-2′), 5.31 (d, 1H, J=6.52 Hz, OH-5′), 5.18 (d, 1H, J=4.46 Hz, OH-3′), 4.56 (q, 1H, J=5.15 Hz, H-2′), 4.09–4.04 (m, 1H, H-3′), 3.98–3.91 (m, 1H, H-4′), 3.68–3.57 (m, 2H, H-5′), 2.86 (d, 3H, J=4.46 Hz, CH3); MS m/z 423 (M+H)+; Anal. (C11H15IN6O4) C, H, N.

Provenance & Evidence