Methanol → HCID 86592813, compound

Participants

Reaction Steps

The reaction was performed with 2-iodo-8-bromoadenosine (5, 90 mg, 0.19 mmol) and ethylamine (2.5 ml, 70% w/v in water). Yield 58.3 mg (0.13 mmol, 70%), mp 205–207÷C, Rƒ 0.15 (10% MeOH in CH2Cl2); 1H NMR (DMSO-d6) δ 6.97 (t, 1H, J=5.15 Hz, NH), 6.89 (s, 2H, NH2), 5.79 (d, 1H, J=7.56 Hz, H-1′), 5.65–5.61 (m, 1H, OH-2′), 5.30 (d, 1H, J=6.18 Hz, OH-5′), 5.18 (d, 1H, J=3.77 Hz, OH-3′), 4.55 (q, 1H, J=6.17 Hz, H-2′), 4.08–4.04 (m, 1H, H-3′), 3.94 (bs, 1H, H-4′), 3.65–3.61 (m, 2H, H-5′), 2.49 (m, 2H, CH2), 1.16 (t, 3H, J=7.21 Hz, CH3); MS m/z 437 (M+H)+; Anal. (C12H17IN6O4) C, H, N.

Provenance & Evidence