Methanol → HCID 86592815, compound

Participants

Reaction Steps

The reaction was performed with 2-iodo-8-bromoadenosine (5, 1.15 g, 2.44 mmol) and n-butylamine (25 ml). Some drops of water were added to dissolve everything. Yield 0.92 g (1.98 mmol, 81%), mp 142–144÷C, Rƒ 0.23 (10% MeOH in CH2Cl2); 1H NMR (DMSO-d6) δ 6.94–6.86 (m, 3H, NH, NH2), 5.79 (d, 1H, J=7.56 Hz, H-1′), 5.67–5.62 (m, 1H, OH-2′), 5.30–5.16 (m, 2H, OH-3′,5′), 4.54–4.49 (m, 1H, H-2′), 4.07–4.04 (m, 1H, H-3′), 3.95–3.92 (m, 1H, H-4′), 3.64–3.57 (m, 2H, H-5′), 2.49–2.42 (m, 2H, NHCH2), 1.55–1.26 (m, 4H, CH2CH2CH3), 0.88 (t, 3H, J=7.21 Hz, CH3); MS m/z 464 (M+H)+; Anal. (C14H21IN6O4) C, H, N.

Provenance & Evidence