1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 21057871, compound

Participants

Reaction Steps

To a solution of 2-Cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid (150 mg, 0.640 mmol), 5-Methyl-2-phenyl-2H-pyrazol-3-ylamine (211 mg, 1.28 mmol) and 1-hydroxybenzotriazole (147 mg, 1.28 mmol) in DMF (5 ml) is added 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (199 mg, 1.28 mmol) at ambient temperature. After being stirred for 15 hours at ambient temperature, the reaction mixture is diluted with ethyl acetate, washed with saturated NaHCO3, dried over MgSO4 and concentrated. The crude product is purified by reverse-phase HPLC to give the product. Rf=0.44 (n-hexane:AcOEt=1:1). 1H NMR (400 MHz, CDCl3) δ 0.98(s, 9H), 2.33(s, 3H), 3.37(d, 2H), 6.55(s, 1H), 7.41-7.53(m,5H), 8.24(s, 1H), 9.01(br, 1H).

Provenance & Evidence