HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 10254925, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone | HCID 6775 | — |
| Reactant | (+/-)-4-Ethyl-6-[4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylvaleroylamino]-2,3-benzoxazin-1-one | HCID 21941663 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 10254925 | HCID 10254925 | 87.5% |
Reaction Steps
930 mg of (±)-4-ethyl-6-[4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylvaleroylamino]-2,3-benzoxazin-1-one and 680 mg of 2,3-dichloro-5,6-dicyano-p-benzoquinone in 90 ml of dioxane are refluxed for 20 hours, mixed with water and suctioned off. After chromatography on silica gel (hexane/ethyl acetate 1.5+1), 810 mg of (±)-4-ethyl-6-[4-(7-benzofuranyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)valeroylamino]-2,3-benzoxazin-1-one is obtained. Flash point 212° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112584B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-e014f83e598f46bc83ba4b22d428924c |
| Source note | uspto-grants-2006_09 |