4,5,6,7-Tetrahydro-benzothiazole-2,6-diamine dihydrobromide → HCID 10209919, compound

HRID 2216320Notes

Reaction equation

HRID 2216320 reaction equation
[C:1]([NH:20][CH2:21][C:22]([N:24]1[CH2:28][CH2:27][CH2:26][C@H:25]1[C:29](O)=[O:30])=[O:23])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br.Br.[S:34]1[C:38]2[CH2:39][CH:40]([NH2:43])[CH2:41][CH2:42][C:37]=2[N:36]=[C:35]1[NH2:44]>>[NH2:44][C:35]1[S:34][C:38]2[CH2:39][CH:40]([NH:43][C:29]([C@@H:25]3[CH2:26][CH2:27][CH2:28][N:24]3[C:22](=[O:23])[CH2:21][NH:20][C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:30])[CH2:41][CH2:42][C:37]=2[N:36]=1

Participants

3

Reactant 2

HCID 136706894,5,6,7-Tetrahydro-benzothiazole-2,6-diamine dihydrobromideHCID 58700739HCID 58700739, compound

Product 1

HCID 10209919HCID 10209919, compoundYield 36%

Procedure

The title compound was prepared from (2S)-1-[2-(Tritylamino)acetyl]-2-pyrrolidinecarboxylic acid and 4,5,6,7-tetrahydro-1,3-benzothiazol-2,6-diamine dihydrobromide according to the procedure described in EXAMPLE 25, and was obtained as a faint yellow crystalline solid.

Workup

  1. customwas obtained as a faint yellow crystalline solid

Sources & evidence

ORD record
ord-13797ff3be8f4bea8ff0f4908d99d5b6
Source dataset
uspto-grants-2006_09
Patent number
US07112590B2

Reaction notes

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