Hydrochloric Acid → HCID 10268604, compound

Participants

Reaction Steps

HCl gas was bubbled for 50 minutes through a solution of tert-butyl (2S)-2-{[(2-amino-1,3-benzothiazol-6-yl)amino]carbonyl}-1-pyrrolidinecarboxylate (2.21 g, 6.1 mmol) in 6 mL of anhydrous acetic acid at room temperature. Acetic acid was evaporated under reduced pressure and the residue was triturated several times with diethyl ether and dried above NaOH to yield 1.35 g (54%) of the title compound as brownish solid.

Provenance & Evidence