HRID2216325

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)[C@H](CC1CCCCC1)C(=O)N1CCC[C@H]1C(=O)O

HCID11730559

未命名化合物

HCID13670689

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)CN(C(=O)OC(C)(C)C)[C@H](CC1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NC1CCc2nc(N)sc2C1

HCID10282836

未命名化合物

收率 65%

PROCEDURE

实验过程

The title compound was prepared from (2S)-1-((2R)-2-{(tert-butoxycarbonyl)[2-(tert-butoxy)-2-oxoethyl]amino}-3-cyclohexylpropanoyl)-2-pyrrolidinecarboxylic acid and 4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrobromide according to the procedure of EXAMPLE 25, and was obtained as a white solid.

WORKUP

后处理

customwas obtained as a white solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-753c64e03bb140c28d83168ad02b3395
来源数据集: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07112590B2
来源说明: uspto-grants-2006_09

反应 SMILES

[C:1]([O:5][C:6]([N:8]([CH2:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C@H:9]([CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[C:10]([N:12]1[CH2:16][CH2:15][CH2:14][C@H:13]1[C:17](O)=[O:18])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].Br.Br.[S:37]1[C:41]2[CH2:42][CH:43]([NH2:46])[CH2:44][CH2:45][C:40]=2[N:39]=[C:38]1[NH2:47]>>[NH2:47][C:38]1[S:37][C:41]2[CH2:42][CH:43]([NH:46][C:17]([C@@H:13]3[CH2:14][CH2:15][CH2:16][N:12]3[C:10](=[O:11])[C@H:9]([N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:20][CH:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:18])[CH2:44][CH2:45][C:40]=2[N:39]=1