HCID 11730559, compound → HCID 10282836, compound

HRID 2216325Notes

Reaction equation

HRID 2216325 reaction equation
[C:1]([O:5][C:6]([N:8]([CH2:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C@H:9]([CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[C:10]([N:12]1[CH2:16][CH2:15][CH2:14][C@H:13]1[C:17](O)=[O:18])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].Br.Br.[S:37]1[C:41]2[CH2:42][CH:43]([NH2:46])[CH2:44][CH2:45][C:40]=2[N:39]=[C:38]1[NH2:47]>>[NH2:47][C:38]1[S:37][C:41]2[CH2:42][CH:43]([NH:46][C:17]([C@@H:13]3[CH2:14][CH2:15][CH2:16][N:12]3[C:10](=[O:11])[C@H:9]([N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:20][CH:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:18])[CH2:44][CH2:45][C:40]=2[N:39]=1

Participants

3

Reactant 2

HCID 11730559HCID 11730559, compoundHCID 136706894,5,6,7-Tetrahydro-benzothiazole-2,6-diamine dihydrobromide

Product 1

HCID 10282836HCID 10282836, compoundYield 65%

Procedure

The title compound was prepared from (2S)-1-((2R)-2-{(tert-butoxycarbonyl)[2-(tert-butoxy)-2-oxoethyl]amino}-3-cyclohexylpropanoyl)-2-pyrrolidinecarboxylic acid and 4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrobromide according to the procedure of EXAMPLE 25, and was obtained as a white solid.

Workup

  1. customwas obtained as a white solid

Sources & evidence

ORD record
ord-753c64e03bb140c28d83168ad02b3395
Source dataset
uspto-grants-2006_09
Patent number
US07112590B2

Reaction notes

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