Dimethylformamide → 1-Benzyl-3-(2-propynyloxy)pyrrolidine

Participants

Reaction Steps

On an ice bath, 233 mg of sodium hydride was added to a mixture of 948 mg of 1-benzyl-3-pyrrolidinol and 10 ml of N,N-dimethylformamide and the mixture was stirred at room temperature for 1 hour. There action mixture was cooled to −40° C. and 495 μl of propargyl bromide was added thereto. The temperature was elevated to room temperature and water and ethyl acetate were added to the reaction mixture. The organic layer was separated, washed with water and brine, dried over anhydrous magnesium sulfate and the solvent was removed. The residue was purified by NH-silica gel column chromatography with 15% ethyl acetate/hexane, to give 507 mg of the title compound.

Provenance & Evidence