Cyclohexanol, 1-ethynyl-, 1-acetate → 1-ethynyl-N-methylcyclohexan-1-amine

HRID 2216363Notes

Reaction equation

C(O[C:5]1([C:11]#[CH:12])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)(=O)C.[CH3:13][NH2:14].CO>>[C:11]([C:5]1([NH:14][CH3:13])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)#[CH:12]

Participants

Reactant 2

HCID 78903Cyclohexanol, 1-ethynyl-, 1-acetate

HCID 57454252Monomethylamine methanol

Product 1

HCID 219422731-ethynyl-N-methylcyclohexan-1-amine

Procedure

This was synthesized in the same manner as in Production Example 18 except that 1-acetoxy-1-ethynylcyclohexane (Production Example 17) and a 40% methylamine/methanol solution were used.

Sources & evidence

ORD record: ord-f981d22908d1432f81f1432a37e1564f
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07112593B2

Reaction notes

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