HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Tartaric acid → (3R)-3-ethynyl-1-azabicyclo[2.2.2]octan-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Tartaric acid | HCID 444305 | — |
| Reactant | 3-Ethynyl-1-azabicyclo[2.2.2]octan-3-ol | HCID 3613517 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (3R)-3-ethynyl-1-azabicyclo[2.2.2]octan-3-ol | HCID 946095 | 13.7% |
Reaction Steps
15.1 g of 3-ethynyl-3-quinuclidinol and 15 g of L-(+)-tartaric acid were dissolved under heating in 300 ml of methanol. After standing to cool, the resulting crystals were collected by filtration and recrystallized from methanol for three times, to give 2.07 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112593B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-045b0c00c94e4f619c268e6d07eafcb6 |
| Source note | uspto-grants-2006_09 |