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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2216377Generated: October 25, 2026

1-(1-Ethynylcyclohexyl)piperidine → 1-[1-[2-Benzyl-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]-3-pyridyl]ethynylcyclohexyl]piperidine

https://huagongshe.com/reaction/2216377

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(1-Ethynylcyclohexyl)piperidineHCID 305916—
Reactant2-Benzyl-3-iodo-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridineHCID 11384307—
Product1-[1-[2-Benzyl-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]-3-pyridyl]ethynylcyclohexyl]piperidineHCID 10140281—

Reaction Steps

This was synthesized in the same manner as in Example 6 except that 2-benzyl-3-iodo-6-[(3R,4R)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridine (Production Example 1) and 1-(1-ethynylcyclohexyl)piperidine (Production Example 18) were used.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07112593B2
Source datasetuspto-grants-2006_09
ORD IDord-963d441d0ddc4828b20bf30088adc23c
Source noteuspto-grants-2006_09