Phenol → Benzonitrile, 5-amino-2-phenoxy-

HRID 2216386Notes

Reaction equation

HRID 2216386 reaction equation
Cl[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][C:3]=1[C:4]#[N:5].[C:13]1([OH:19])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[NH2:10][C:7]1[CH:8]=[CH:9][C:2]([O:19][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:3]([CH:6]=1)[C:4]#[N:5]

Participants

3

Reactant 2

HCID 996PhenolHCID 855042-Chloro-5-nitrobenzonitrile

Product 1

HCID 21942386Benzonitrile, 5-amino-2-phenoxy-Yield 26.1%

Procedure

By the reaction and treatment in the same manner as in Starting Material Synthetic Example 2 using 2-chloro-5-nitrobenzonitrile (10 g) and phenol (5.7 g), the title compound (3 g) was obtained. melting point: 89° C.

Workup

  1. customBy the reaction and treatment in the same manner as

Sources & evidence

ORD record
ord-89a5ba7e01d045818c20f90582465b23
Source dataset
uspto-grants-2006_09
Patent number
US07112594B2

Reaction notes

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