Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2216391Generated: October 25, 2026

1-Methylpiperazine → 5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile

https://huagongshe.com/reaction/2216391

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylpiperazineHCID 53167—
Reactant2-Chloro-5-nitrobenzonitrileHCID 85504—
Product5-Amino-2-(4-methylpiperazin-1-yl)benzonitrileHCID 1760958162.5%

Reaction Steps

By the reaction and treatment in the same manner as in Starting Material Synthetic Example 4 using 2-chloro-5-nitrobenzonitrile (15 g) and methylpiperazine (9.8 g), the title compound (11.1 g) was obtained. melting point: 45-46° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07112594B2
Source datasetuspto-grants-2006_09
ORD IDord-58fcb8b3c4f747289de79d546576b89c
Source noteuspto-grants-2006_09