HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-nitrobenzonitrile → 5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-nitrobenzonitrile | HCID 85504 | — |
| Reactant | 1-(Oxan-4-yl)piperazine | HCID 21942315 | — |
| Product | 5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]benzonitrile | HCID 21942323 | 66.9% |
Reaction Steps
By the reaction and treatment in the same manner as in Starting Material Synthetic Example 4 using 2-chloro-5-nitrobenzonitrile (10 g) and 4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazine (27 g), the title compound (10.5 g) was obtained. melting point: 162° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112594B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-d6f6c937ca09450885e4333a9e991381 |
| Source note | uspto-grants-2006_09 |