Benzo(b)thiophene-2-carboxylic acid → HCID 21058043, compound

HRID 2216412Notes

Reaction equation

HRID 2216412 reaction equation
[S:1]1[C:5]([C:6]([OH:8])=O)=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.[NH2:13][C:14]1[CH:15]=[CH:16][C:17]([N:22]([CH2:26][CH2:27][OH:28])[CH2:23][CH2:24][OH:25])=[C:18]([CH:21]=1)[C:19]#[N:20]>>[OH:25][CH2:24][CH2:23][N:22]([C:17]1[CH:16]=[CH:15][C:14]([NH:13][C:6]([C:5]2[S:1][C:2]3[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=3[CH:4]=2)=[O:8])=[CH:21][C:18]=1[C:19]#[N:20])[CH2:26][CH2:27][OH:28]

Participants

3

Reactant 2

HCID 95864Benzo(b)thiophene-2-carboxylic acidHCID 219423665-Amino-2-[bis(2-hydroxyethyl)amino]benzonitrile

Product 1

HCID 21058043HCID 21058043, compoundYield 19.3%

Procedure

By the reaction and treatment in the same manner as in Example 6 using benzo[b]thiophene-2-carboxylic acid (1.0 g) and 5-amino-2-[N,N-bis(2-hydroxyethyl)amino]benzonitrile (0.9 g), the title compound (0.3 g) was obtained. melting point: 163-168° C.

Sources & evidence

ORD record
ord-7d5597deb08646689c233aad32daced2
Source dataset
uspto-grants-2006_09
Patent number
US07112594B2

Reaction notes

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