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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2216415Generated: November 2, 2026

Benzo(b)thiophene-2-carboxylic acid → N-[3-cyano-4-(4-(2-hydroxyethyl)piperidin-1-yl)phenyl]benzo[b]thiophene-2-carboxamide

https://huagongshe.com/reaction/2216415

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzo(b)thiophene-2-carboxylic acidHCID 95864—
Reactant5-Amino-2-[4-(2-hydroxyethyl)piperidin-1-yl]benzonitrileHCID 21942359—
ProductN-[3-cyano-4-(4-(2-hydroxyethyl)piperidin-1-yl)phenyl]benzo[b]thiophene-2-carboxamideHCID 2194233334.6%

Reaction Steps

By the reaction and treatment in the same manner as in Example 6 using benzo[b]thiophene-2-carboxylic acid (1.5 g) and 5-amino-2-[4-(2-hydroxyethyl)piperidin-1-yl]benzonitrile (1.4 g), the title compound (0.8 g) was obtained. melting point: 218° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07112594B2
Source datasetuspto-grants-2006_09
ORD IDord-ed48ac9dd4ab4b3182e5372cc93bd66f
Source noteuspto-grants-2006_09