HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzofuran-2-carboxylic acid → N-{3-cyano-4-[4-(2-hydroxyethyl)piperidin-1-yl]phenyl}benzo[b]furan-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzofuran-2-carboxylic acid | HCID 10331 | — |
| Reactant | 5-Amino-2-[4-(2-hydroxyethyl)piperidin-1-yl]benzonitrile | HCID 21942359 | — |
| Product | N-{3-cyano-4-[4-(2-hydroxyethyl)piperidin-1-yl]phenyl}benzo[b]furan-2-carboxamide | HCID 21942314 | 10.5% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 7 using benzo[b]furan-2-carboxylic acid (2 g) and 5-amino-2-[4-(2-hydroxyethyl)piperidin-1-yl]benzonitrile (3 g), the title compound (0.5 g) was obtained. melting point: 214° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112594B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-2bb25ee915a24d6aaa59327850031c7b |
| Source note | uspto-grants-2006_09 |