HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzo(b)thiophene-2-carboxylic acid → N-[4-(1-benzylpiperidin-4-yloxy)-3-cyanophenyl]benzo[b]thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzo(b)thiophene-2-carboxylic acid | HCID 95864 | — |
| Reactant | 5-Amino-2-(1-benzylpiperidin-4-yloxy)benzonitrile | HCID 21942352 | — |
| Product | N-[4-(1-benzylpiperidin-4-yloxy)-3-cyanophenyl]benzo[b]thiophene-2-carboxamide | HCID 21942340 | 32.9% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 6 using benzo[b]thiophene-2-carboxylic acid (0.7 g) and 5-amino-2-(1-benzylpiperidine-4-yloxy)benzonitrile (1.2 g), the title compound (0.6 g) was obtained. melting point: 206° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112594B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-89c718e89ecb42bda8bbe6e0f930fa2e |
| Source note | uspto-grants-2006_09 |