HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzofuran-2-carboxylic acid → N-[4-(1-benzylpiperidin-4-yloxy)-3-cyanophenyl]benzo[b]furan-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzofuran-2-carboxylic acid | HCID 10331 | — |
| Reactant | 5-Amino-2-(1-benzylpiperidin-4-yloxy)benzonitrile | HCID 21942352 | — |
| Product | N-[4-(1-benzylpiperidin-4-yloxy)-3-cyanophenyl]benzo[b]furan-2-carboxamide | HCID 21942361 | 40.2% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 6 using benzo[b]furan-2-carboxylic acid (1.2 g) and 5-amino-2-(1-benzylpiperidin-4-yloxy)benzonitrile (2.2 g), the title compound (1.3 g) was obtained. melting point: 175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112594B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-af1a8d79fb014e09b57fcc13d5d45d6d |
| Source note | uspto-grants-2006_09 |