HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzo(b)thiophene-2-carboxylic acid → N-[3-cyano-4-(4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl)phenyl]benzo[b]thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzo(b)thiophene-2-carboxylic acid | HCID 95864 | — |
| Reactant | 5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]benzonitrile | HCID 21942323 | — |
| Product | N-[3-cyano-4-(4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl)phenyl]benzo[b]thiophene-2-carboxamide | HCID 21942380 | 64.1% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 6 using benzo[b]thiophene-2-carboxylic acid (0.4 g) and 5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-4-yl)piperazin-1-yl]benzonitrile (0.6 g), the title compound (0.6 g) was obtained. melting point: >285° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112594B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-249bb8c699ed493fb41a07ff118ca139 |
| Source note | uspto-grants-2006_09 |