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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2216427Generated: November 2, 2026

2-Naphthoic acid → N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]naphthalene-2-carboxamide

https://huagongshe.com/reaction/2216427

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Naphthoic acidHCID 7123—
Reactant5-Amino-2-(4-hydroxypiperidin-1-yl)benzonitrileHCID 21942313—
ProductN-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]naphthalene-2-carboxamideHCID 2194238767.9%

Reaction Steps

By the reaction and treatment in the same manner as in Example 6 using naphthalene-2-carboxylic acid (0.44 g) and 5-amino-2-(4-hydroxypiperidin-1-yl)benzonitrile (0.5 g), the title compound (0.58 g) was obtained. melting point: 183-185° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07112594B2
Source datasetuspto-grants-2006_09
ORD IDord-15c27f683eed46d8b389c35aa113ce0c
Source noteuspto-grants-2006_09