1,2,3,4-Tetrahydro-2-naphthoic acid → N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide

HRID 2216428Notes

Reaction equation

HRID 2216428 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[C:11]([OH:13])=O.[NH2:14][C:15]1[CH:16]=[CH:17][C:18]([N:23]2[CH2:28][CH2:27][CH:26]([OH:29])[CH2:25][CH2:24]2)=[C:19]([CH:22]=1)[C:20]#[N:21]>>[C:20]([C:19]1[CH:22]=[C:15]([NH:14][C:11]([CH:2]2[CH2:3][CH2:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH2:1]2)=[O:13])[CH:16]=[CH:17][C:18]=1[N:23]1[CH2:28][CH2:27][CH:26]([OH:29])[CH2:25][CH2:24]1)#[N:21]

Participants

3

Reactant 2

HCID 1013701,2,3,4-Tetrahydro-2-naphthoic acidHCID 219423135-Amino-2-(4-hydroxypiperidin-1-yl)benzonitrile

Product 1

HCID 21942381N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-1,2,3,4-tetrahydronaphthalene-2-carboxamideYield 59.4%

Procedure

By the reaction and treatment in the same manner as in Example 6 using 1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (0.45 g) and 5-amino-2-(4-hydroxypiperidin-1-yl)benzonitrile (0.58 g), the title compound (0.57 g) was obtained. melting point: 163-165° C.

Sources & evidence

ORD record
ord-68364f6ec7d84d51a79b245853a4bc5a
Source dataset
uspto-grants-2006_09
Patent number
US07112594B2

Reaction notes

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