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HRID221645

反应详情

EQUATION

反应方程式

HRID 221645 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[Si](C)(C)Oc1ccc(OCC2CO2)cc1
HCID19385012

未命名化合物

结构：NC1CCN(c2ncnc3scc(-c4ccc(F)cc4)c23)CC1
HCID69040995

未命名化合物

PRODUCTS

生成物

1
结构：Oc1ccc(OCC(O)CNC2CCN(c3ncnc4scc(-c5ccc(F)cc5)c34)CC2)cc1
HCID24936491

未命名化合物

收率 45%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O.CS(C)=O
溶剂HCID87082799

未命名化合物

PROCEDURE

实验过程

Synthesis followed SP6 (iPrOH:DMSO 1:1, 10 h), using 200 μmol tert-butyldimethyl(4-(oxiran-2-ylmethoxy)phenoxy)silane and 1-(5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine to give O-silylated intermediate upon purification by prep. HPLC (reversed phase) with 45% yield. Product was obtained by deprotection according to SP7 and purification by prep. HPLC (reversed phase) with 74% yield.

WORKUP

后处理

  1. customSynthesis
  2. customto give O-silylated intermediate
  3. customupon purification by prep
  4. customProduct was obtained by deprotection
  5. customaccording to SP7 and purification by prep