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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 221649Generated: October 29, 2026

(3-(Oxiran-2-ylmethoxy)phenyl)methanol → 1-(3-(Hydroxymethyl)phenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol

https://huagongshe.com/reaction/221649

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-(Oxiran-2-ylmethoxy)phenyl)methanolHCID 19385010—
Reactant1-(5-Phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amineHCID 69041562—
Product1-(3-(Hydroxymethyl)phenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-olHCID 2493726964%

Reaction Steps

Synthesis followed SP6 (4 h), using 150 μmol (3-(oxiran-2-ylmethoxy)phenyl)methanol and 1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine to give the title compound with 64% yield upon purification by prep. HPLC (reversed phase).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08207174B2
Source datasetuspto-grants-2012_06
ORD IDord-fdf0cbef06484360adbe6d002898be4a
Source noteuspto-grants-2012_06