HCID 11258624, compound → HCID 135850859, compound

HRID 2216518Notes

Reaction equation

HRID 2216518 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:19]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[N:18]=[C:17]([CH2:26][CH2:27][C:28]([O:30][CH3:31])=[O:29])[CH:16]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[CH:20]1([N:19]2[C:15]([C:12]3[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=3)=[CH:16][C:17]([CH2:26][CH2:27][C:28]([O:30][CH3:31])=[O:29])=[N:18]2)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

4

Reactant 1

HCID 11258624HCID 11258624, compound

Product 1

HCID 135850859HCID 135850859, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of methyl ester 6.1 (71.5 mg, 0.172 mmol) in MeOH (4 ml) was added 20 mg 10% Pd-C prior to atmosphere evacuation and flushed with H2 (3×). The reaction mixture was stirred under H2 for 2 h, filtered, and concentrated to give 54 mg (96%) of 6.3. MS (ESI) 329.3 (MH+), 327.3 (MH−).

Workup

  1. customto atmosphere evacuation and flushed with H2 (3×)
  2. filtrationfiltered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-d324bb9dabc84563a33263ee58f85c06
Source dataset
uspto-grants-2006_09
Patent number
US07112601B2

Reaction notes

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